The aim of this study was to examine changes of blood biochemical parameters and egg composition in Caspian Kutum broodstock (Rutilus frisii) at the final stage of reproduction. At the end of spawning season, 15 matured females of the Caspian Kutum divided into three groups of pre-spawning, spawning and post-spawning captured from Sefidrod River in the south part of the Caspian Sea. Blood sampling and stripping were carried out in each group of broodstocks and blood biochemical parameters (triglyceride, glucose, cholesterol and total protein) and egg components (moisture, protein, lipid and ash) were measured. Analysis of biochemical parameters showed significant differences in plasma triglyceride in pre-spawning fish with the other two groups. Plasma glucose level in fish which were ready to spawn were significantly different from the other two groups. No significant differences were found for total protein and cholesterol levels. A significant difference was found between broodstocks in moisture, protein, lipid and ash contacts of the eggs. Significant correlation was found between blood total protein and egg protein in pre and post-spawning broodstocks. Also a significant correlation was observed in pre-spawning group in terms of blood triglyceride and egg fat content. The results indicate that blood biochemical parameters and egg composition can alter and have some fluctuations at the final stages of reproduction in female Caspian Kutum broodstock.