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Protective effects of astaxanthin against oxidative stress caused by diazinon in rainbow trout (Oncorhynchus mykiss) gil
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Sadigheh Shabanzadeh1   , Saber Vatandoust1 , Seyed Mehdi Hosseinifard2 , Najmeh Sheikhzadeh * , Amir ali Shahbazfar4 |
1- Department of Fisheries, Babol Branch, Islamic Azad University, Babol, Iran.
2- Department of Veterinary, Babol Branch, Islamic Azad University, Babol, Iran.
University of Tabriz, Department of Food Hygiene and Aquatic Animals, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. , nsheikh@tabrizu.ac.ir
4- Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. |
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Abstract: (1003 Views) |
| The current study was performed to evaluate the protective effects of astaxanthin against diazinon exposure on the gill biochemical and gene expression indices in rainbow trout. Fish were fed with different doses (0.5, 2 and 5 g kg-1) commercial astaxanthin for 60 days. After the feeding trial, fish were challenged with 0.11 mg L-1 diazinon for 96 hours. After the in vivo test, fish gills were sampled to study the biochemical factors and antioxidant-relevant gene expressions. Results showed that feeding astaxanthin could decrease lipid peroxidation products and improve gill antioxidant status. Meanwhile, mRNA expression levels related to some antioxidant enzymes, including superoxide dismutase, glutathione S-transferase, glutathione peroxidase and nuclear factor erythroid-2 related factor 2 (Nrf2), were up-regulated in the fish fed astaxanthin following the challenge with diazinon. Even though no significant changes in catalase mRNA expression level was observed. Present study suggests that astaxanthin could mitigate the oxidative stress induced by diazinon in rainbow trout gill. |
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| Keywords: Astaxanthin, diazinon, gill, rainbow trout, antioxidant system. |
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Full-Text [PDF 462 kb]
(387 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2021/10/3 | Accepted: 2021/11/29 | Published: 2023/05/31
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