:: Volume 17, Issue 1 (5-2023) ::
JAD 2023, 17(1): 41-53 Back to browse issues page
Protective effects of astaxanthin against oxidative stress caused by diazinon in rainbow trout (Oncorhynchus mykiss) gil
Sadigheh Shabanzadeh , Saber Vatandoust , Seyed Mehdi Hosseinifard , Najmeh Sheikhzadeh * , Amir ali Shahbazfar
University of Tabriz
Abstract:   (588 Views)
The current study was performed to evaluate the protective effects of astaxanthin against diazinon exposure on the gill biochemical and gene expression indices in rainbow trout. Fish were fed with different doses (0.5, 2 and 5 g kg-1) commercial astaxanthin for 60 days. After the feeding trial, fish were challenged with 0.11 mg L-1 diazinon for 96 hours. After the in vivo test, fish gills were sampled to study the biochemical factors and antioxidant-relevant gene expressions. Results showed that feeding astaxanthin could decrease lipid peroxidation products and improve gill antioxidant status. Meanwhile, mRNA expression levels related to some antioxidant enzymes, including superoxide dismutase, glutathione S-transferase, glutathione peroxidase and nuclear factor erythroid-2 related factor 2 (Nrf2), were up-regulated in the fish fed astaxanthin following the challenge with diazinon. Even though no significant changes in catalase mRNA expression level was observed. Present study suggests that astaxanthin could mitigate the oxidative stress induced by diazinon in rainbow trout gill.
Keywords: Astaxanthin, diazinon, gill, rainbow trout, antioxidant system.
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Type of Study: Research | Subject: Special
Received: 2021/10/3 | Accepted: 2021/11/29 | Published: 2023/05/31

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Volume 17, Issue 1 (5-2023) Back to browse issues page