Background and Objectives: white spot disease (WSD) in shrimps causes heavy losses in shrimp farming in the country. Various studies have reported different physical and chemical factors in water for WSD incidence. The purpose of this study was to determine the rate of studied risk factors in WSD incidence in shrimp culture farms in West Bahu Kalat (Southeastern Iran) by logistic regression model. Methods: Some factors in water such as: temperature, salinity, oxygen, pH, ammonia, silica, transparency and the amount of phytoplankton and some management factors from 12 pounds of shrimp culture farms located in Sistan and Baluchestan province during two years (2010 and 2011) were measured and recorded. 1180 cultured Litopenaeus vannamei from 12 pounds were tested for identification of the white spot virus (WSV) by Nested-PCR method. Results: The data analysis with software (PASW Statistics 18, SPSS) showed effects of oxygen, temperature and transparency factors in incidence of WSD in the studied area. Conclusion: Some risk factors were more importance than others and some risk factors had not affected the incidence of WSD in this study. It seems that WSD incidence related to some ecology of studied area and biologic of host factors are not measured in this study.